MRN_complex

The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast). In eukaryotes, the MRN/X complex plays an important role in the initial processing of double-strand DNA breaks prior to repair by homologous recombination or non-homologous end joining. The MRN complex binds avidly to double-strand breaks both in vitro and in vivo and may serve to tether broken ends prior to repair by non-homologous end joining or to initiate resection prior to repair by homologous recombination. The MRN complex also participates in activating the checkpoint kinase ATM in response to DNA damage. Production of short single-strand oligonucleotides by Mre11 endonuclease activity has been implicated in ATM activation by the MRN complex. (hgnc.genefamily:1344)

Cross-references

Synonyms

Synonym Reference Specificity
Mre11/Rad50 (M/R) DNA-repair complex Exact
MRN complex Exact

Incoming Relations

Identifier Name Relation
HGNC:26157 WDCP partof
HGNC:7652 NBN partof
HGNC:9816 RAD50 partof
HGNC:7230 MRE11 partof

Outgoing Relations

None available.