A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC. (mesh:D019255)



Synonym Reference Specificity
NAD(P)H oxidase Exact
NAD(P)H-oxidase Exact
NADPH oxidase Exact

Incoming Relations

Identifier Name Relation
HGNC:7660 NCF1 partof
HGNC:2577 CYBA partof
HGNC:7661 NCF2 partof
HGNC:2578 CYBB partof
HGNC:3062 DUOX1 partof
HGNC:14874 NOX5 partof
HGNC:9801 RAC1 partof
HGNC:7889 NOX1 partof
HGNC:13273 DUOX2 partof
HGNC:7891 NOX4 partof
HGNC:7890 NOX3 partof
HGNC:7662 NCF4 partof

Outgoing Relations

None available.