NFAT

A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. (mesh:D050778)

Cross-references

• MESH:D050778 - NFATC Transcription Factors
• NCIT:C17903
• IP:IPR008366
• BEL:NFAT Family
• SFAM:F0148

Synonyms

Synonym	Reference	Specificity
NFAT		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:7774	NFAT5	isa
HGNC:7775	NFATC1	isa
HGNC:7776	NFATC2	isa
HGNC:7777	NFATC3	isa
HGNC:7778	NFATC4	isa

Outgoing Relations

None available.