A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. (mesh:D050778)



Synonym Reference Specificity
NFAT Exact

Incoming Relations

Identifier Name Relation
HGNC:7778 NFATC4 isa
HGNC:7774 NFAT5 isa
HGNC:7776 NFATC2 isa
HGNC:7777 NFATC3 isa
HGNC:7775 NFATC1 isa

Outgoing Relations

None available.