P90RSK

A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN. (mesh:D038744)

Cross-references

• BEL:RPS6KA Family
• SFAM:F0210
• RE:R-HSA-446849
• IP:IPR016239
• SIGNOR:SIGNOR-PF26
• MEDSCAN:urn:agi-protfc:p90rsk
• MESH:D038744 - Ribosomal Protein S6 Kinases, 90-kDa

Synonyms

Synonym	Reference	Specificity
RPS6KA		Exact
p90RSK		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:10432	RPS6KA3	isa
HGNC:10431	RPS6KA2	isa
HGNC:10433	RPS6KA4	isa
HGNC:10435	RPS6KA6	isa
HGNC:10434	RPS6KA5	isa
HGNC:10430	RPS6KA1	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:RSK	RSK