PDE1

A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP. (mesh:D054677)

Cross-references

• SFAM:F0162
• RE:R-HSA-111952
• MESH:D054677 - Cyclic Nucleotide Phosphodiesterases, Type 1
• GO:GO:0004117 - calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
• BEL:PDE1 Family
• IP:IPR013706
• RE:R-HSA-111953

Synonyms

Synonym	Reference	Specificity
phosphodiesterase-1		Exact
Phosphodiesterase 1		Exact
PDE1 family		Exact
PDE1		Exact
phosphodiesterase 1		Exact
Phosphodiesterase-1		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:8774	PDE1A	isa
HGNC:8776	PDE1C	isa
HGNC:8775	PDE1B	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:PDE	PDE