PDE3

A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. (mesh:D054684)

Cross-references

• SFAM:F0163
• NXP:FA:00803
• BEL:PDE3 Family
• MEDSCAN:urn:agi-protfc:phosphodiesterase%20III
• MESH:D054684 - Cyclic Nucleotide Phosphodiesterases, Type 3

Synonyms

Synonym	Reference	Specificity
phosphodiesterase 3		Exact
PDE3 family		Exact
PDE3		Exact
PDE 3		Exact
Phosphodiesterase 3		Exact
Phosphodiesterase-3		Exact
phosphodiesterase-3		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:8778	PDE3A	isa
HGNC:8779	PDE3B	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:PDE	PDE