PDE4

A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes. (mesh:D054703)

Cross-references

• NCIT:C107433
• MEDSCAN:urn:agi-protfc:PDE4%20subfamily
• NXP:FA:00804
• SFAM:F0164
• RE:R-HSA-111960
• MESH:D054703 - Cyclic Nucleotide Phosphodiesterases, Type 4
• BEL:PDE4 Family

Synonyms

Synonym	Reference	Specificity
PDE4 family		Exact
phosphodiesterase-4		Exact
type 4 cyclic nucleotide phosphodiesterase		Exact
PDE4 isoforms		Exact
Phosphodiesterase 4		Exact
Phosphodiesterase-4		Exact
PDE4		Exact
phosphodiesterase 4		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:8780	PDE4A	isa
HGNC:8783	PDE4D	isa
HGNC:8781	PDE4B	isa
HGNC:8782	PDE4C	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:PDE	PDE