PDE6

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme. (mesh:D054707)

Cross-references

• MESH:D054707 - Cyclic Nucleotide Phosphodiesterases, Type 6
• BEL:PDE6 Family
• MEDSCAN:urn:agi-aopfc:0000704
• SFAM:F0168

Synonyms

Synonym	Reference	Specificity
PDE6		Exact
Phosphodiesterase 6		Exact
PDE6 family		Exact
phosphodiesterase-6		Exact
phosphodiesterase 6		Exact
Phosphodiesterase-6		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:8787	PDE6C	isa
HGNC:8785	PDE6A	isa
HGNC:8786	PDE6B	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:PDE	PDE