PDH

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) (mesh:D011768)

Cross-references

• BEL:Pyruvate Dehydrogenase Complex
• MESH:D011768 - Pyruvate Dehydrogenase Complex
• SCOMP:C0107

Synonyms

Synonym	Reference	Specificity
PDH		Exact
pyruvate dehydrogenase (acetyl-transferring)		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:8806	PDHA1	partof
HGNC:2896	DLAT	partof
HGNC:2898	DLD	partof
HGNC:21350	PDHX	partof
HGNC:8807	PDHA2	partof
HGNC:8808	PDHB	partof

Outgoing Relations

None available.