A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) (mesh:D011768)



Synonym Reference Specificity
PDH Exact
pyruvate dehydrogenase (acetyl-transferring) Exact

Incoming Relations

Identifier Name Relation
HGNC:2898 DLD partof
HGNC:8808 PDHB partof
HGNC:21350 PDHX partof
HGNC:2896 DLAT partof
HGNC:8806 PDHA1 partof
HGNC:8807 PDHA2 partof

Outgoing Relations

None available.