An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (mesh:D011493)



Synonym Reference Specificity
PKC Exact
protein kinase C Exact

Incoming Relations

Identifier Name Relation
HGNC:9410 PRKCQ isa
HGNC:9399 PRKCD isa
HGNC:9408 PRKD3 isa
HGNC:9393 PRKCA isa
HGNC:9403 PRKCH isa
HGNC:9401 PRKCE isa
HGNC:9412 PRKCZ isa
HGNC:9395 PRKCB isa
HGNC:9402 PRKCG isa
HGNC:9404 PRKCI isa

Outgoing Relations

None available.