PPP2C

One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5. (mesh:D000071636)

Cross-references

• BEL:PPP2C Family
• MESH:D000071636 - Protein Phosphatase 2C
• SFAM:F0186

Synonyms

Synonym	Reference	Specificity
PP2Ac		Exact
PP2A catalytic C subunit		Exact
PP2A-C		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:20785	PPM1J	isa
HGNC:9300	PPP2CB	isa
HGNC:9299	PPP2CA	isa

Outgoing Relations

Relation	Identifier	Name
partof	FPLX:PPP2	PPP2