One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5. (mesh:D000071636)



Synonym Reference Specificity
PP2Ac Exact
PP2A catalytic C subunit Exact
PP2A-C Exact

Incoming Relations

Identifier Name Relation
HGNC:9299 PPP2CA isa
HGNC:9300 PPP2CB isa
HGNC:20785 PPM1J isa

Outgoing Relations

Relation Identifier Name
partof FPLX:PPP2 PPP2