PPP3

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes. (mesh:D019703)

Cross-references

• BEL:Calcineurin Complex
• BEL:PPP3 Family
• SFAM:F0189
• MEDSCAN:urn:agi-complex:protein%20phosphatase%203
• MESH:D019703 - Calcineurin
• SCOMP:C0030

Synonyms

Synonym	Reference	Specificity
CaN		Exact
protein phosphatase 2B		Exact
PP2B		Exact
calcineurin		Exact

Incoming Relations

Identifier	Name	Relation
FPLX:PPP3C	PPP3C	partof
FPLX:PPP3R	PPP3R	partof

Outgoing Relations

None available.