PPP3

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes. (mesh:D019703)

Cross-references

Synonyms

Synonym Reference Specificity
PP2B Exact
calcineurin Exact
CaN Exact
protein phosphatase 2B Exact

Incoming Relations

Identifier Name Relation
FPLX:PPP3R PPP3R partof
FPLX:PPP3C PPP3C partof

Outgoing Relations

None available.