A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme. (mesh:D046988)
| Synonym | Reference | Specificity |
| proteasome endopeptidase | Exact | |
| proteasome | Exact |
| Identifier | Name | Relation |
| HGNC:9571 | PSMF1 | partof |
| HGNC:9565 | PSMD7 | partof |
| HGNC:9543 | PSMB6 | partof |
| HGNC:9545 | PSMB8 | partof |
| HGNC:9541 | PSMB4 | partof |
| HGNC:9532 | PSMA3 | partof |
| HGNC:9536 | PSMA7 | partof |
| HGNC:9535 | PSMA6 | partof |
| HGNC:9531 | PSMA2 | partof |
| HGNC:9556 | PSMD11 | partof |
| HGNC:9540 | PSMB3 | partof |
| HGNC:9548 | PSMC2 | partof |
| HGNC:9564 | PSMD6 | partof |
| HGNC:9549 | PSMC3 | partof |
| HGNC:9567 | PSMD9 | partof |
| HGNC:9554 | PSMD1 | partof |
| HGNC:9559 | PSMD2 | partof |
| HGNC:9566 | PSMD8 | partof |
| HGNC:9530 | PSMA1 | partof |
| HGNC:9544 | PSMB7 | partof |
| HGNC:9568 | PSME1 | partof |
| HGNC:9542 | PSMB5 | partof |
| HGNC:9555 | PSMD10 | partof |
| HGNC:9551 | PSMC4 | partof |
| HGNC:9561 | PSMD4 | partof |
| HGNC:22985 | PSMA8 | partof |
| HGNC:9537 | PSMB1 | partof |
| HGNC:9569 | PSME2 | partof |
| HGNC:9538 | PSMB10 | partof |
| HGNC:9558 | PSMD13 | partof |
| HGNC:12628 | USP5 | partof |
| HGNC:9533 | PSMA4 | partof |
| HGNC:9539 | PSMB2 | partof |
| HGNC:9547 | PSMC1 | partof |
| HGNC:9560 | PSMD3 | partof |
| HGNC:9534 | PSMA5 | partof |
| HGNC:9552 | PSMC5 | partof |
| HGNC:9557 | PSMD12 | partof |
| HGNC:10845 | SEM1 | partof |
| HGNC:9546 | PSMB9 | partof |
| HGNC:9553 | PSMC6 | partof |
| HGNC:16889 | PSMD14 | partof |
| HGNC:9570 | PSME3 | partof |
| HGNC:9563 | PSMD5 | partof |