A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme. (mesh:D046988)



Synonym Reference Specificity
proteasome endopeptidase Exact
proteasome Exact

Incoming Relations

Identifier Name Relation
HGNC:9558 PSMD13 partof
HGNC:9554 PSMD1 partof
HGNC:9556 PSMD11 partof
HGNC:9570 PSME3 partof
HGNC:9533 PSMA4 partof
HGNC:9537 PSMB1 partof
HGNC:9557 PSMD12 partof
HGNC:9535 PSMA6 partof
HGNC:9565 PSMD7 partof
HGNC:9536 PSMA7 partof
HGNC:9552 PSMC5 partof
HGNC:9563 PSMD5 partof
HGNC:9571 PSMF1 partof
HGNC:22985 PSMA8 partof
HGNC:9564 PSMD6 partof
HGNC:9542 PSMB5 partof
HGNC:9551 PSMC4 partof
HGNC:9545 PSMB8 partof
HGNC:9559 PSMD2 partof
HGNC:9566 PSMD8 partof
HGNC:9553 PSMC6 partof
HGNC:9531 PSMA2 partof
HGNC:9532 PSMA3 partof
HGNC:9530 PSMA1 partof
HGNC:9544 PSMB7 partof
HGNC:9548 PSMC2 partof
HGNC:9555 PSMD10 partof
HGNC:16889 PSMD14 partof
HGNC:9560 PSMD3 partof
HGNC:9561 PSMD4 partof
HGNC:9569 PSME2 partof
HGNC:10845 SEM1 partof
HGNC:12628 USP5 partof
HGNC:9538 PSMB10 partof
HGNC:9567 PSMD9 partof
HGNC:9546 PSMB9 partof
HGNC:9534 PSMA5 partof
HGNC:9541 PSMB4 partof
HGNC:9549 PSMC3 partof
HGNC:9543 PSMB6 partof
HGNC:9547 PSMC1 partof
HGNC:9568 PSME1 partof
HGNC:9540 PSMB3 partof
HGNC:9539 PSMB2 partof

Outgoing Relations

None available.