A family of eukaryotic transcription factors that recognize and bind to a highly-conserved cis-regulatory sequence (X-box) within the promoter region of MHC CLASS II GENES. They contain a conserved winged-helix DNA binding domain and function as homo or heterodimers. (mesh:D000071701)



Synonym Reference Specificity
RFX proteins Exact
regulatory family X Exact
RFX family Exact
RF-X Exact
RFX Exact

Incoming Relations

Identifier Name Relation
HGNC:25777 RFX7 isa
HGNC:37253 RFX8 isa
HGNC:9986 RFX5 isa
HGNC:9985 RFX4 isa
HGNC:21478 RFX6 isa
HGNC:9982 RFX1 isa
HGNC:9984 RFX3 isa
HGNC:9983 RFX2 isa

Outgoing Relations

None available.