RIPK

A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment. (mesh:D053422)

Cross-references

• MESH:D053422 - Receptor-Interacting Protein Serine-Threonine Kinases

Synonyms

Synonym	Reference	Specificity
RIPK		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:10020	RIPK2	isa
HGNC:10019	RIPK1	isa

Outgoing Relations

None available.