A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment. (mesh:D053422)



Synonym Reference Specificity
RIPK Exact

Incoming Relations

Identifier Name Relation
HGNC:10019 RIPK1 isa
HGNC:10020 RIPK2 isa

Outgoing Relations

None available.