ROCK

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES. (mesh:D054460)

Cross-references

• SFAM:F0208
• MESH:D054460 - rho-Associated Kinases
• BEL:ROCK Family
• RE:R-HSA-419057
• IP:IPR015008
• RE:R-HSA-4687776
• IP:IPR020684

Synonyms

Synonym	Reference	Specificity
Rho kinase		Exact
ROCK		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:10251	ROCK1	isa
HGNC:10252	ROCK2	isa

Outgoing Relations

None available.