A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES. (mesh:D054460)



Synonym Reference Specificity
Rho kinase Exact
ROCK Exact

Incoming Relations

Identifier Name Relation
HGNC:10251 ROCK1 isa
HGNC:10252 ROCK2 isa

Outgoing Relations

None available.