A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects. (mesh:D057050)



Synonym Reference Specificity
RORs Exact
receptor tyrosine kinase-like orphan receptors Exact
ROR Exact
receptor tyrosine kinase-like orphan receptor Exact

Incoming Relations

Identifier Name Relation
HGNC:10257 ROR2 isa
HGNC:10256 ROR1 isa

Outgoing Relations

None available.