RSK

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. (mesh:D019893)

Cross-references

• MESH:D019893 - Ribosomal Protein S6 Kinases

Synonyms

Synonym	Reference	Specificity
RSK		Exact

Incoming Relations

Identifier	Name	Relation
FPLX:P70S6K	P70S6K	isa
FPLX:P90RSK	P90RSK	isa

Outgoing Relations

None available.