SGC

A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals. (mesh:D000071756)

Cross-references

• MESH:D000071756 - Soluble Guanylyl Cyclase

Synonyms

Synonym	Reference	Specificity
sGC		Exact
Soluble guanylyl cyclase		Exact
Soluble Guanylate Cyclase		Exact
Soluble guanylyl/guanylate cyclase		Exact

Incoming Relations

Identifier	Name	Relation
FPLX:GUCY1B	GUCY1B	partof
FPLX:GUCY1A	GUCY1A	partof

Outgoing Relations

None available.