SGC

A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals. (mesh:D000071756)

Cross-references

Synonyms

Synonym Reference Specificity
Soluble guanylyl cyclase Exact
Soluble Guanylate Cyclase Exact
sGC Exact
Soluble guanylyl/guanylate cyclase Exact

Incoming Relations

Identifier Name Relation
FPLX:GUCY1B GUCY1B partof
FPLX:GUCY1A GUCY1A partof

Outgoing Relations

None available.