STAT

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT. (mesh:D050791)

Cross-references

• NCIT:C19618
• IP:IPR013801
• MEDSCAN:urn:agi-complex:prophash-2de597c3f4a807f3caeaf02e5f93ce15
• MESH:D050791 - STAT Transcription Factors
• IP:IPR013799
• IP:IPR015988
• IP:IPR013800
• SFAM:F0225
• IP:IPR001217
• IP:IPR012345
• MEDSCAN:urn:agi-aopfc:0000163
• BEL:STAT Family

Synonyms

Synonym	Reference	Specificity
STAT		Exact
STATs		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:11364	STAT3	isa
FPLX:STAT5	STAT5	isa
HGNC:11368	STAT6	isa
HGNC:11362	STAT1	isa
HGNC:11365	STAT4	isa
HGNC:11363	STAT2	isa

Outgoing Relations

None available.