Sodium_voltage_gated_channel_alpha_subunits

Sodium channels are voltage-gated sodium-selective ion channels present in the membrane of most excitable cells. Sodium channels comprise of one pore-forming α subunit, which may be associated with either one or two beta subunits. Alpha-subunits consist of four homologous domains (I–IV), each containing six transmembrane segments (S1–S6) and a pore-forming loop. The positively charged fourth transmembrane segment (S4) acts as a voltage sensor and is involved in channel gating. (hgnc.genefamily:1203)

Cross-references

• HGNC_GROUP:1203

Synonyms

None available.

Incoming Relations

Identifier	Name	Relation
HGNC:10585	SCN1A	isa
HGNC:10590	SCN3A	isa
HGNC:10583	SCN11A	isa
HGNC:10588	SCN2A	isa
HGNC:10597	SCN9A	isa
HGNC:10596	SCN8A	isa
HGNC:10593	SCN5A	isa
HGNC:10582	SCN10A	isa
HGNC:10591	SCN4A	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:SCN	SCN