Sodium_voltage_gated_channel_alpha_subunits

Sodium channels are voltage-gated sodium-selective ion channels present in the membrane of most excitable cells. Sodium channels comprise of one pore-forming α subunit, which may be associated with either one or two beta subunits. Alpha-subunits consist of four homologous domains (I–IV), each containing six transmembrane segments (S1–S6) and a pore-forming loop. The positively charged fourth transmembrane segment (S4) acts as a voltage sensor and is involved in channel gating. (hgnc.genefamily:1203)

Cross-references

Synonyms

None available.

Incoming Relations

Identifier Name Relation
HGNC:10582 SCN10A isa
HGNC:10591 SCN4A isa
HGNC:10583 SCN11A isa
HGNC:10585 SCN1A isa
HGNC:10588 SCN2A isa
HGNC:10590 SCN3A isa
HGNC:10596 SCN8A isa
HGNC:10593 SCN5A isa
HGNC:10597 SCN9A isa

Outgoing Relations

Relation Identifier Name
isa FPLX:SCN SCN