TAP

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. (mesh:D018435)

Cross-references

• MESH:D018435 - ATP Binding Cassette Transporter, Subfamily B
• GO:GO:0042825 - TAP complex
• BEL:TAP Family
• SFAM:F0228

Synonyms

Synonym	Reference	Specificity
TAP		Exact
TAP transporter		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:44	TAP2	isa
HGNC:43	TAP1	isa
HGNC:50	ABCB9	isa

Outgoing Relations

None available.