TAP

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. (mesh:D018435)

Cross-references

Synonyms

Synonym Reference Specificity
TAP Exact
TAP transporter Exact

Incoming Relations

Identifier Name Relation
HGNC:43 TAP1 isa
HGNC:44 TAP2 isa
HGNC:50 ABCB9 isa

Outgoing Relations

None available.