TGFB
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
(mesh:D016212)
Cross-references
Synonyms
| Synonym |
Reference |
Specificity |
| transforming growth factor-β |
|
Exact
|
| TGFB family |
|
Exact
|
| TGF beta |
|
Exact
|
| TGFβ |
|
Exact
|
| TGF-beta family |
|
Exact
|
| TGF-b |
|
Exact
|
| TGF-beta |
|
Exact
|
| TGF β |
|
Exact
|
| transforming growth factor-beta |
|
Exact
|
| transforming growth factor beta |
|
Exact
|
| TGFbeta |
|
Exact
|
| transforming growth factor β |
|
Exact
|
| TGFB |
|
Exact
|
| TGF-β |
|
Exact
|
Incoming Relations
Outgoing Relations
None available.