A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. (mesh:D016212)



Synonym Reference Specificity
transforming growth factor-β Exact
TGFB family Exact
TGF beta Exact
TGFβ Exact
TGF-beta family Exact
TGF-b Exact
TGF-beta Exact
TGF β Exact
transforming growth factor-beta Exact
transforming growth factor beta Exact
TGFbeta Exact
transforming growth factor β Exact
TGFB Exact
TGF-β Exact

Incoming Relations

Identifier Name Relation
HGNC:11769 TGFB3 isa
HGNC:11768 TGFB2 isa
HGNC:11766 TGFB1 isa

Outgoing Relations

None available.