THBS

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair. (mesh:D019699)

Cross-references

• BEL:THBS Family
• IP:IPR017897
• SFAM:F0233
• IP:IPR008859
• MEDSCAN:urn:agi-protfc:thrombospondins
• IP:IPR003367
• IP:IPR028974
• MESH:D019699 - Thrombospondins

Synonyms

Synonym	Reference	Specificity
thrombospondin protein		Exact
Thrombospondin		Exact
thrombospondins		Exact
thrombospondin		Exact
Thrombospondins		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:11788	THBS4	isa
HGNC:11785	THBS1	isa
HGNC:2227	COMP	isa
HGNC:11787	THBS3	isa
HGNC:11786	THBS2	isa

Outgoing Relations

None available.