THBS

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair. (mesh:D019699)

Cross-references

Synonyms

Synonym Reference Specificity
thrombospondin Exact
Thrombospondin Exact
thrombospondins Exact
Thrombospondins Exact
thrombospondin protein Exact

Incoming Relations

Identifier Name Relation
HGNC:2227 COMP isa
HGNC:11786 THBS2 isa
HGNC:11788 THBS4 isa
HGNC:11787 THBS3 isa
HGNC:11785 THBS1 isa

Outgoing Relations

None available.