TOP

Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA. (mesh:D026942)

Cross-references

• MESH:D026942 - DNA Topoisomerases
• HGNC_GROUP:1050

Synonyms

Synonym	Reference	Specificity
topoisomerase		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:11986	TOP1	isa
FPLX:TOP2	TOP2	isa
HGNC:11992	TOP3A	isa
HGNC:11993	TOP3B	isa
HGNC:29787	TOP1MT	isa

Outgoing Relations

None available.