TOP2

DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex. (mesh:D004250)

Cross-references

• IP:IPR013759
• IP:IPR013757
• IP:IPR024946
• IP:IPR012542
• IP:IPR034157
• MESH:D004250 - DNA Topoisomerases, Type II
• NCIT:C18434
• SFAM:F0237
• IP:IPR018522
• IP:IPR002205
• BEL:TOP2 Family
• IP:IPR001154
• IP:IPR013760
• IP:IPR013506
• IP:IPR001241
• IP:IPR013758
• IP:IPR031660

Synonyms

Synonym	Reference	Specificity
topoisomerase II		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:11990	TOP2B	isa
HGNC:11989	TOP2A	isa

Outgoing Relations

Relation	Identifier	Name
isa	FPLX:TOP	TOP