TRP

A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES. (mesh:D050051)

Cross-references

Synonyms

None available.

Incoming Relations

Identifier Name Relation
HGNC:18082 TRPV2 isa
HGNC:14006 TRPV6 isa
HGNC:17992 TRPM3 isa
HGNC:12338 TRPC6 isa
HGNC:18084 TRPV3 isa
HGNC:12337 TRPC5 isa
HGNC:12335 TRPC3 isa
HGNC:12333 TRPC1 isa
HGNC:14323 TRPM5 isa
HGNC:17994 TRPM7 isa
HGNC:18083 TRPV4 isa
HGNC:497 TRPA1 isa
HGNC:9012 PKD2L2 isa
HGNC:17993 TRPM4 isa
HGNC:9009 PKD2 isa
HGNC:13358 MCOLN3 isa
HGNC:7146 TRPM1 isa
HGNC:13356 MCOLN1 isa
HGNC:17995 TRPM6 isa
HGNC:20754 TRPC7 isa
HGNC:12339 TRPM2 isa
HGNC:17961 TRPM8 isa
HGNC:12716 TRPV1 isa
HGNC:9011 PKD2L1 isa
HGNC:3145 TRPV5 isa
HGNC:12334 TRPC2 isa
HGNC:12336 TRPC4 isa
HGNC:13357 MCOLN2 isa

Outgoing Relations

Relation Identifier Name
isa FPLX:Voltage_gated_ion_channels Voltage_gated_ion_channels
isa FPLX:Mechanosensitive_ion_channels Mechanosensitive_ion_channels