Troponin_I

A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY. (mesh:D019210)

Cross-references

• MESH:D019210 - Troponin I
• NCIT:C17343
• RE:R-HSA-390541

Synonyms

Synonym	Reference	Specificity
TPNI		Exact
troponin I		Exact
cTnI		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:11945	TNNI1	isa
HGNC:11946	TNNI2	isa
HGNC:11947	TNNI3	isa

Outgoing Relations

Relation	Identifier	Name
partof	FPLX:Troponin	Troponin