A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY. (mesh:D019210)



Synonym Reference Specificity
TPNI Exact
cTnI Exact
troponin I Exact

Incoming Relations

Identifier Name Relation
HGNC:11947 TNNI3 isa
HGNC:11946 TNNI2 isa
HGNC:11945 TNNI1 isa

Outgoing Relations

Relation Identifier Name
partof FPLX:Troponin Troponin