The USP (ubiquitin-specific protease) family is a family of deubiquitinating enzymes characterized by the presence of a USP domain, which is a conserved catalytic domain. USP enzymes are cysteine proteases.
| Identifier | Name | Relation |
| HGNC:12619 | USP20 | isa |
| HGNC:20074 | PAN2 | isa |
| FPLX:USP9 | USP9 | isa |
| HGNC:18563 | USP29 | isa |
| HGNC:20080 | USP45 | isa |
| HGNC:12623 | USP24 | isa |
| HGNC:20059 | USP33 | isa |
| HGNC:12624 | USP25 | isa |
| HGNC:12627 | USP4 | isa |
| HGNC:12613 | USP15 | isa |
| HGNC:20078 | USP49 | isa |
| HGNC:12617 | USP19 | isa |
| HGNC:12611 | USP13 | isa |
| HGNC:20069 | USP40 | isa |
| HGNC:20072 | USP43 | isa |
| HGNC:20065 | USP30 | isa |
| FPLX:USP17L | USP17L | isa |
| HGNC:12631 | USP8 | isa |
| HGNC:13485 | USP26 | isa |
| HGNC:12607 | USP1 | isa |
| FPLX:USPL | USPL | isa |
| HGNC:12608 | USP10 | isa |
| HGNC:12625 | USP28 | isa |
| HGNC:12630 | USP7 | isa |
| HGNC:20070 | USP41 | isa |
| HGNC:12621 | USP22 | isa |
| HGNC:12620 | USP21 | isa |
| HGNC:20075 | USP46 | isa |
| HGNC:29255 | USP53 | isa |
| HGNC:18533 | USP48 | isa |
| HGNC:12629 | USP6 | isa |
| HGNC:20060 | USP31 | isa |
| HGNC:13486 | USP27X | isa |
| HGNC:20071 | USP39 | isa |
| HGNC:20076 | USP47 | isa |
| HGNC:12618 | USP2 | isa |
| HGNC:23086 | USP51 | isa |
| HGNC:12628 | USP5 | isa |
| HGNC:20063 | USP37 | isa |
| HGNC:12609 | USP11 | isa |
| HGNC:20485 | USP12 | isa |
| HGNC:20067 | USP38 | isa |
| HGNC:20064 | USP44 | isa |
| HGNC:20066 | USP34 | isa |
| HGNC:20061 | USP35 | isa |
| HGNC:12614 | USP16 | isa |
| HGNC:23513 | USP54 | isa |
| HGNC:12626 | USP3 | isa |
| HGNC:12616 | USP18 | isa |
| HGNC:12612 | USP14 | isa |
| HGNC:20079 | USP50 | isa |
| HGNC:20068 | USP42 | isa |
| HGNC:20062 | USP36 | isa |
| HGNC:19143 | USP32 | isa |
| Relation | Identifier | Name |
| isa | FPLX:Deubiquitinase | Deubiquitinase |