mTORC1

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS. (mesh:D000076222)

Cross-references

• GO:GO:0031931 - TORC1 complex
• SCOMP:C0124
• BEL:TORC1 Complex
• MEDSCAN:urn:agi-complex:prophash-f472fef3f59301aee0b776702a30f03e
• SIGNOR:SIGNOR-C3
• MESH:D000076222 - Mechanistic Target of Rapamycin Complex 1
• NCIT:C96314

Synonyms

Synonym	Reference	Specificity
mTORC1		Exact
TORC1		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:3942	MTOR	partof
HGNC:30287	RPTOR	partof

Outgoing Relations

None available.