mTORC1

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS. (mesh:D000076222)

Cross-references

Synonyms

Synonym Reference Specificity
TORC1 Exact
mTORC1 Exact

Incoming Relations

Identifier Name Relation
HGNC:30287 RPTOR partof
HGNC:3942 MTOR partof

Outgoing Relations

None available.