mTORC2

A multiprotein complex consisting of MTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like MTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to MTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation. (mesh:D000076225)

Cross-references

• SCOMP:C0125
• NCIT:C96315
• MESH:D000076225 - Mechanistic Target of Rapamycin Complex 2
• BEL:TORC2 Complex
• SIGNOR:SIGNOR-C2
• MEDSCAN:urn:agi-complex:prophash-0d528c29d63997f87f62e4fbd9f0b168

Synonyms

Synonym	Reference	Specificity
mTORC2		Exact
TORC2		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:3942	MTOR	partof
HGNC:24825	MLST8	partof
HGNC:18752	MAPKAP1	partof
HGNC:28611	RICTOR	partof

Outgoing Relations

None available.