p14_3_3

A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins. (mesh:D048948)

Cross-references

• IP:IPR000308
• PF:PF00244
• MEDSCAN:urn:agi-protfc:14-3-3
• MESH:D048948 - 14-3-3 Proteins
• SFAM:F0001
• RE:R-HSA-2457842
• IP:IPR023409
• IP:IPR023410
• RE:R-HSA-1445138
• BEL:14-3-3 Family
• SIGNOR:SIGNOR-PF7

Synonyms

Synonym	Reference	Specificity
14-3-3 proteins		Exact
14-3-3		Exact

Incoming Relations

Identifier	Name	Relation
HGNC:12855	YWHAZ	isa
HGNC:12853	YWHAH	isa
HGNC:12851	YWHAE	isa
HGNC:10773	SFN	isa
HGNC:12854	YWHAQ	isa
HGNC:12849	YWHAB	isa
HGNC:12852	YWHAG	isa

Outgoing Relations

None available.