A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins. (mesh:D048948)



Synonym Reference Specificity
14-3-3 Exact
14-3-3 proteins Exact

Incoming Relations

Identifier Name Relation
HGNC:12849 YWHAB isa
HGNC:12852 YWHAG isa
HGNC:10773 SFN isa
HGNC:12851 YWHAE isa
HGNC:12853 YWHAH isa
HGNC:12854 YWHAQ isa
HGNC:12855 YWHAZ isa

Outgoing Relations

None available.