The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4. (mesh:D039001)



Synonym Reference Specificity
integrin alpha Exact

Incoming Relations

Identifier Name Relation
HGNC:6136 ITGA11 isa
HGNC:6139 ITGA3 isa
HGNC:6145 ITGA9 isa
HGNC:6148 ITGAL isa
HGNC:6144 ITGA8 isa
HGNC:6140 ITGA4 isa
HGNC:6150 ITGAV isa
HGNC:6146 ITGAD isa
HGNC:6152 ITGAX isa
HGNC:6134 ITGA1 isa
HGNC:6135 ITGA10 isa
HGNC:6141 ITGA5 isa
HGNC:6142 ITGA6 isa
HGNC:6149 ITGAM isa
HGNC:6147 ITGAE isa
HGNC:6137 ITGA2 isa
HGNC:6138 ITGA2B isa
HGNC:6143 ITGA7 isa

Outgoing Relations

Relation Identifier Name
isa FPLX:Integrins Integrins