An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase. (mesh:D038982)



Synonym Reference Specificity
alpha2beta1 integrin Exact

Incoming Relations

Identifier Name Relation
HGNC:6153 ITGB1 partof
HGNC:6137 ITGA2 partof

Outgoing Relations

Relation Identifier Name
isa FPLX:Integrins Integrins