Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling. (mesh:D039641)



None available.

Incoming Relations

Identifier Name Relation
HGNC:6158 ITGB4 isa
HGNC:6163 ITGB8 isa
HGNC:6164 ITGBL1 isa
HGNC:6156 ITGB3 isa
HGNC:6155 ITGB2 isa
HGNC:6160 ITGB5 isa
HGNC:6162 ITGB7 isa
HGNC:6161 ITGB6 isa
HGNC:6153 ITGB1 isa

Outgoing Relations

Relation Identifier Name
isa FPLX:Integrins Integrins